MCQ for MBBS Students

1. The drug used for malaria chemoprophylaxis and treatment: 
a) Chloroquine 
b) Quinidine 
c) Quinine 
d) Sulfonamides 

2. All of the following antimalarial drugs are 4-quinoline derivatives, EXCEPT: 
a) Chloroquine 
b) Mefloquine 
c) Primaquine 
d) Amodiaquine 

3. The antimalarial drug belonging to pyrimidine derivatives: 
a) Mefloquine 
b) Pyrimethamine 
c) Quinidine 
d) Chloroquine 

4. The antimalarial drug having a gametocidal effect: 
a) Mefloquine 
b) Primaquine 
c) Doxycycline 
d) Sulfonamides 

5.  All of the following antimalarial drugs influence blood schizonts, EXCEPT: 
a) Mefloquine 
b) Chloroquine 
c) Primaquine 
d) Quinidine 

6.  the antimalarial drug which is tissue schisonticidal: 
a) Mefloquine 
b) Chloroquine 
c) Quinidine 
d) Primaquine 

7.  The group of antibiotics having an antimalarial effect: 
a) Aminoglycosides 
b) Tetracyclins 
c) Carbapenems 
d) Penicillins 

8. Which of the following antimalarial drug is used for the radical cure of P. vivax?

a) Mefloquine 
b) Chloroquine 
c) Quinidine 
d) Primaquine 

9. Which of these phases of malarial parasite is the target for prophylactic treatment?
a. Pre-erythrocytic phase in liver
b. Erythrocytic phase
c. Exo-erythrocytic phase
d. Any of the above

10. Which of these drugs is not used for prophylaxis of malaria?
a. Quinine
b. Chloroquine
c. Primaquine
d. Chloroguanide

11. Chloroquine as a prophylactic drug is used in the following dose:
a. 100mg (base) weekly
b. 200mg (base) weekly
c. 300 mg (base)weekly
d. 400mg (base) weekly

12. Which of the following enzyme deficiency should be ruled out before starting Primaquine therapy?

a. G6PD (Glucose 6 phosphate dehydrogenase)
b. lysosomal enzymes
c. Pancreatic lipase
d. Pancreatic amylase

13. Primaquine as a radical cure for malaria is used in the following dosage:

a. 15 mg daily for one week
b. 15 mg daily for 2 weeks
c. 15 mg daily for three weeks
d. 15 mg daily for four weeks

14.  One cycle of liver invasion and multiplication: 
A) P vivax
B) P falciparum
C) P. malariae
D) P ovale

15. Antimalarials which is/are dihydrofolate reductase inhibitors

A) chloroquine 
B) chloroguanide
C) pyrimethamine 
D) trimethoprim 
E) primaquine

16.  Treatment must eliminate parasites from both liver and erythrocytes in malaria due to: 
A) P falciparum
B) P. malariae
C) P vivax
D) P ovale

17.  Of the plasmodium species causative for human malaria, the one producing most serious complications: 

A) Plasmodium vivax
B) Plasmodium malariae
C) Plasmodium ovale
D) plasmodium falciparum

18. The sexual phase in malarial parasite occurs in 
a. Human   b. Anopheles   c. Both    d. None

19. Quinine which is used for malaria treatment is extracted from 
a. Cinchona    b. Cinnamon    c. Coriander   d. Quircus

20. The most common side effect of quinine 
a. coma   b. deafness    c. headache    d. respiratory depression

21. Cinchonism side effect is seen with which of the following antimalarial drugs
a. Quinine
b. Chloroquine
c. Primaquine
d. Mefloquine

22. A 25 year old female is suffering from acute attack of malaria due to P. vivax. He is given chloroquine for this attack, but to prevent future relapse of such attack he must be given
a. Mefloquine
b. Quinine
c. Primaquine
d. Proguanil
e. Fansidar

23.  Which one of the following anti-malarial drugs is a blood schizonticide against all four types of malarial parasites, is gametocidal against all forms except Plasmodium Falciparum and is also used for suppressive prophylaxis but is not active against liver stage malarial parasites?

a)      Artemether       b)  Chloroquine     c)  Fansidar     d) Mefloquine    e) Primaquine

24. The symptoms of malaria can be alleviated by suppressing the blood schizonticides. Which one of the following terms is used to describe this?

a)      Causal Prophylaxis

b)     Radical Cure

c)      Suppressive Cure

 d)     Suppressive Prophylaxis

 e)      Terminal Prophylaxis

25. Glucose-6-phosphate dehydrogenase (G6PDH) deficiency is an inherited error of metabolism. The enzyme is needed to reduce oxidized glutathione, and in deficient persons, red blood cells are susceptible to haemolysis in the presence of oxidising agents, including certain drugs. The antimalarial drug to avoid in G6PDH deficiency is
A primaquine
B quinine
C chloroquine
D chloroguanide
E amodiaquine